| 摘要 |
PROBLEM TO BE SOLVED: To provide a pharmaceutical formulation that is stabilized against deamidation and aggregation. SOLUTION: The invention relates to a pharmaceutical formulation including growth hormone, an amino acid selected from the group of Asp, Ile, Val and Leu, or a derivative of histidine, or a peptide including at least one basic amino acid residue and at least one acidic amino acid residue, and a nonionic detergent, e.g. polysorbate or poloxamer. The pharmaceutical formulation may be an aqueous composition. The growth hormone may be human growth hormone. COPYRIGHT: (C)2009,JPO&INPIT |
