发明名称 |
A NON-DESTRUCTIVE METHOD TO QUANTIFY AND ISOLATE ANTIGEN-SPECIFIC B CELLS AND USES THEREOF |
摘要 |
The present invention relates to antigen-Ig Ab fusion molecules and methods of using same, wherein antigen-Ig Ab fusion molecules include an antigen fused to an immunoglobulin molecule, fragment or variant thereof and wherein the fusing of the immunoglobulin molecule to the antigen does not alter the specificity or tertiary structure of important epitopes of the antigen. This method allows the direct quantification and isolation of antigen-specific B cells by flow cytometry in essentially any species.
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申请公布号 |
CA2719522(A1) |
申请公布日期 |
2008.10.02 |
申请号 |
CA20082719522 |
申请日期 |
2008.03.26 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
FLINKO, ROBIN;LEWIS, GEORGE K.;DEVICO, ANTHONY L. |
分类号 |
A61K39/00;C07K16/00;C12N5/00;G01N33/53;G01N33/566 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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