PROCESS FOR PRODUCTION OF ASYMMETRIC TETRASUBSTITUTED QUINOLONECARBOXYLIC ACIDS AND INTERMEDIATES FOR THE PRODUCTION

摘要

The invention makes it possible to produce, industrially and easily, optically active compounds for constructing substituents in the production of extremely safe quinolone- carboxylic acids having high antibacterial activity. Intermediate compounds represented by the general formula (5) are produced by treating a compound represented by the general formula (3) in the presence of a metal catalyst and a hydrogen source (wherein n is 2 to 5; R<SUP>1</SUP> is alkyl or aryl; R<SUP>6</SUP> is alkyl, aryl, or hydrogen; and one of R<SUP>71</SUP> and R<SUP>72</SUP> is aryl and the other is aryl, alkyl, alkenyl, aralkyl, or hydrogen). (3)(5)