TOPICAL DERMAL DELIVERY DEVICE FOR NITRIC OXIDE DELIVERY

摘要

A topical dermal delivery device, such as a patch, for topical delivery o f nitric oxide (NO) to treatment sites of mammals is disclosed. In an embodi ment the patch has three layers; a backing with an activation window, a abso rbent core as a reservoir and an NO permeable membrane with an adhesive laye r towards the skin. The NO donor is applied into the device as a solution pr ior to application through the activation window. The window is closed after activation and the lid and backing is non-permeable for NO in order to incr ease the partial pressure of NO and thus the concentration of dissolved NO. The patch is fixated on the area to be treated with an adhesive layer that a lso assures sufficient contact throughout the treatment. The generated NO mo ves within the patch and can escape through the NO permeable membrane toward s the area to be treated. Depending on therapy needed, the patch release cur ve differs and is chosen accordingly.