IMPROVED PROCESS FOR PREPARING DONEPEZIL HYDROCHLORIDE POLYMORPHIC FORM I

摘要

The invention relates to improved methods for preparing polymorph Form I of 2,3- dihydro-5,6-dimethoxy-2-[[ 1 -(phenylmethy l)-4-piperidinyl]methyl- 1H-inden- 1 -one hydrochloride (i.e., donepezil hydrochloride).