COMPOSITIONS AND METHODS FOR IMPROVING THE BIOAVAILABILITY OF LIOTHYRONINE

摘要

The present invention is directed to sustained release pharmaceutical compositions that include a thyroid hormone, such as liothyronine or a pharmaceutically acceptable salt thereof. More specifically, the present invention is directed to sustained release pharmaceutical compositions that include liothyronine, or a pharmaceutically acceptable salt thereof that are capable of maintaining the plasma concentration of liothyronine above the baseline concentration over an extended period of time while mitigating or even eliminating the initial, acute plasma concentration peak of liothyronine, characteristic of immediate release formulations.