发明名称 |
POLYPEPTIDE TARGETING TO MITOCHONDRIA |
摘要 |
<p>Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.</p> |
申请公布号 |
EP1974034(A1) |
申请公布日期 |
2008.10.01 |
申请号 |
EP20060820567 |
申请日期 |
2006.12.19 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
MINCZUK, MICHAEL;PAPWORTH, MONIKA;KLUG, AARON |
分类号 |
C12N15/11;C07K19/00;C12N15/79 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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