发明名称 |
SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF |
摘要 |
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active inhibitor moiety in proximity to a target protease. In certain instances, compounds inhibit proteasomes and/or post-proline cleaving enzymes (PPCE), such as dipeptidyl peptidase IV. The compounds of the invention provide a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease. |
申请公布号 |
EP1973548(A2) |
申请公布日期 |
2008.10.01 |
申请号 |
EP20060849964 |
申请日期 |
2006.12.15 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
LAI, HUNG-SEN;WU, WENGEN;BACHOVCHIN, WILLIAM, W. |
分类号 |
C07F5/02;A61K31/401;A61K31/4045;A61P3/08;C07D207/10;C07D207/16;C07D403/06;C07K5/00;C07K5/117 |
主分类号 |
C07F5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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