STABILIZED ALPHA HELICAL PEPTIDES AND USES THEREOF
摘要
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
申请公布号
EP1680443(A4)
申请公布日期
2008.09.24
申请号
EP20040811198
申请日期
2004.11.05
申请人
DANA-FARBER CANCER INSTITUTE, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE