发明名称 |
FUNCTIONAL ARRAYS FOR HIGH THROUGHPUT CHARACTERIZATION OF REGULATORY ELEMENTS IN UNTRANSLATED REGIONS OF GENES |
摘要 |
This invention provides libraries of expression constructs having different untranslated regions (UTR) from a genome. The expression constructs include transcription regulatory sequences operably linked with a reporter gene and a 5' UTR, a 3' UTR or both, wherein the translation of the reporter gene is under the regulatory control of control regions in the UTR sequence. The libraries of this invention are useful for determining the impact of regulatory sequences in the UTRs on translation of open reading frames under a variety of conditions, such as different cellular environments. |
申请公布号 |
WO2008112127(A2) |
申请公布日期 |
2008.09.18 |
申请号 |
WO2008US02995 |
申请日期 |
2008.03.05 |
申请人 |
SWITCHGEAR GENOMICS;TRINKLEIN, NATHAN;ALDRED, SHELLEY, FORCE |
发明人 |
TRINKLEIN, NATHAN;ALDRED, SHELLEY, FORCE |
分类号 |
C40B40/06;C40B30/06;C40B40/02;C40B60/08;G06Q30/00 |
主分类号 |
C40B40/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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