发明名称 |
Surface-modified base matrices |
摘要 |
The present invention is a surface-modified base matrix comprised of a porous polymeric base matrix onto which branched hydrophilic polyhydroxy-functional polymers have been covalently attached, wherein the polyhydroxy-functional polymers are hyperbranched polymers presenting a degree of branching (DB) of at least about 0.2 and each polymer is tethered to the base matrix at two or more points. The present matrix can for example be a cross-linked carbohydrate material, such as agarose, and the hyperbranched hydrophilic polymer can e.g. be a copolymer of epichiorohydrin and a sugar. The invention also relates to a method of surface-modification of a porous base matrix by activating functional hydroxy groups thereon and contacting the activated matrix with a hydrophilic hyperbranched hydroxy-functional polymer.
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申请公布号 |
US7423070(B2) |
申请公布日期 |
2008.09.09 |
申请号 |
US20040517293 |
申请日期 |
2004.12.07 |
申请人 |
GE HEALTHCARE BIO-SCIENCES AB |
发明人 |
LARSSON ANDERS;MEYER ULRIKA;STRIDSBERG FRIDEN KAJSA;VON HEIJNE EVA |
分类号 |
B01J20/281;C08J7/16;B01D15/32;B01D15/36;B01D15/38;B01J20/26;B01J20/285;B01J39/26;B01J41/20;C08B37/00;C08G81/00;C08G83/00;C08J7/12;G01N30/56;G01N30/88 |
主分类号 |
B01J20/281 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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