Surface-functionalized carrier material and solid phase synthesis method

摘要

The invention concerns a novel surface-functionalized carrier material with a polymeric surface and at least one linker compound according to the general formula (I), which is covalently bound to the surface. In the formula, P indicates the polymeric surface; R² has the meaning OR⁴ or NR⁴R⁵ and R¹, R⁴ and R⁵, independently of one another, indicate H, an alkyl group or an aryl group; R³ indicates H, an alkyl, an aryl, an acyl, an alkoxycarbonyl or an aryloxycarbonyl group; and the alkyl, aryl, acyl, alkoxycarbonyl and/or aryloxycarbonyl group of the radicals R¹, R³, R⁴ and R⁵, independently of one another, are substituted or unsubstituted. The material according to the invention can be very easily produced by photochemical coupling and serves for the solid-phase synthesis of amino acids, peptides, proteins or molecules with at least one peptidic structural unit.