| 摘要 |
organic chemistry, chemistry of peptides, oncology. SUBSTANCE: invention describes novel peptides of the general formula (I): (CH3)2-N- CHX-CO-A-B-D-E-K where A means valine residue; B means N-methylvaline residue; D means proline residue; E means proline residue; X means isopropyl-group; K means , NH-cyclohexyl, NH- cycloheptyl, or and their physiologically tolerant salts. New compounds show an antitumor activity. These compounds show high resistance to decomposition as compared with the known analogues, for example, dolastatine-10 or dolastatine-15 and they can be used orally. EFFECT: new peptides indicated above, valuable medicinal and chemical properties. 4 cl, 2 ex
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