发明名称 |
System and Methods for Stretching Polynucleotides |
摘要 |
Apparatus and methods are described for achieving uniform stretching of polynucleotides in hybrid electrophoretic-gel, micro-constricting microfluidic channels. Polynucleotides in normally relaxed configurations are driven by an electric field along a microfluidic channel. The polynucleotides thread through a porous gel barrier formed in the channel and extend into a constriction where an electric field gradient exists. The combined action of the gel and field gradient acts to extend the polynucleotide configuration fully for direct linear analysis of the molecule.
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申请公布号 |
US2008213912(A1) |
申请公布日期 |
2008.09.04 |
申请号 |
US20070868174 |
申请日期 |
2007.10.05 |
申请人 |
RANDALL GREG;DOYLE PATRICK |
发明人 |
RANDALL GREG;DOYLE PATRICK |
分类号 |
G01N33/58;B01J19/00;G01N21/01;G01N27/26;G03F7/00 |
主分类号 |
G01N33/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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