IMPROVED MEDICINAL COMPOSITIONS COMPRISING BUPRENORPHINE ANDNALTREXONE

摘要

An analgesic composition, in parenteral unit dosage form or in a unit dos age form suitable for delivery via the dermis or mucosa, comprises buprenorp hine and an amount of naltrexone such that the ratio by weight of buprenorph ine to naltrexone delivered to or reaching the plasma of a patient is in the range 100:1 to 5000:1. The analgesic action of the buprenorphine is potenti ated by the low dose of naltrexone. Also provided are a method of treatment of pain and the use of buprenorphine and naltrexone for the manufacture of a medicament.