Low-dose tablets for oral administration are produced by direct compression of microgranules comprising an active ingredient layer on a release-modifying polymer layer on an inert support

摘要

New low-dose tablets are produced by direct compression of microgranules comprising an active ingredient layer on a release-modifying polymer layer on an inert support. Independent claims are also included for: (1) producing the tablets by wetting the support, dusting the support with the polymer, spraying with a solution containing the active ingredient, and drying and compressing the resulting microgranules; (2) microgranules as above; (3) a functionalized excipient comprising a release-modifying polymer layer on an inert support.