ANTAGONIST OX40 ANTIBODIES AND THEIR USE IN THE TREATMENT OFINFLAMMATORY AND AUTOIMMUNE DISEASES

摘要

The present invention relates to antagonist antibodies directed against h uman OX40 receptor (CD 134) and fragments thereof, including the amino acid sequences of antagonist antibodies and the nucleic acids that encode the ant ibodies. Also included in the present invention are antigen binding regions (CDRs) derived from the light and/or heavy chain variable regions of said an tibodies. Another aspect of the present invention is the use of anti-OX40 an tagonist antibodies in the treatment of inflammatory and autoimmune diseases . The present invention also relates to humanized sequences of an antagonist antibody AlO and epitope mapping of the binding site of the antibody.