SUCCINATE DERIVATIVES AND THEIR THERAPEUTIC USE

摘要

A compound of formula (I) wherein R<SUP>1</SUP> is C<SUB>1-4</SUB> alkyl, allyl or propargyl; R<SUP>2</SUP> is C<SUB>1-6</SUB> alkyl, -(CH<SUB>2</SUB>)<SUB>m</SUB>-aryl or -(CH<SUB>2</SUB>)<SUB>m</SUB>-heteroaryl; R<SUP>3</SUP> is H or C<SUB>1-4</SUB> alkyl; R<SUP>4</SUP> is C<SUB>1-4</SUB> alkyl, -(CH<SUB>2</SUB>)<SUB>n</SUB>-aryl or -(CH<SUB>2</SUB>)<SUB>n</SUB>-heteroaryl; R<SUP>5</SUP> is H, OH or C<SUB>1-4</SUB> alkoxy; and m and n independently represent 0 or an integer of up to 3; or a pharmaceutically acceptable salt or solvate thereof, has utility in the treatment of conditions such as atopic dermatitis.