| 摘要 |
<p>Crystal form of besipirdine chlorhydrate (Form I) corresponding to the Formula (A) below: the aforementioned form being characterized at least by one of the following physico-chemical properties: a) In FTIR, it displays at least the following absorption bands of the infrared spectrum: 778, 1198, 1121 , but not the following absorption bands of the infrared spectrum: 3395, 1583, 732, the aforementioned bands being expressed in cm<sup>-1</sup> at ± 5 cm<sup>-1</sup>; b) In PXRD, it shows at least the following reflections, which are the most intense ones but whose intensity hereafter is given for information only:Formula (II) c) In DSC, it displays at least an endothermic peak at 187,3 ± 2,0 °C using 5 °C/min scanning conditions, and a fusion enthalpy οH of 130,4 ± 2,0 J/g. The invention also relates to the processes used for the preparation of form I as well as its applications in urology.</p> |
