| 摘要 |
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequencewherein ffandfare absent or are amino acid residues; fis W; fis an amino acid residue; fis T or I ; f' is K, R, or H ; fis C, a neutral polar residue, or a basic residue; fis C, a neutral polar residue or is absent; and fis any amino acid residue or is absent; provided that only one of fforfmay be C, and only one of f, fand fmay be C. The invention further comprises compositions of matter of the formula (X)-V-(X)wherein Vis a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain. |
