发明名称 |
Diagnosis and treatment of malignant neoplasms |
摘要 |
The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.
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申请公布号 |
US2010093002(A1) |
申请公布日期 |
2010.04.15 |
申请号 |
US20070974076 |
申请日期 |
2007.10.10 |
申请人 |
WANDS JACK R;DE LA MONTE SUZANNE M;DEUTCH ALAN H;GHANBARI HOSSEIN A |
发明人 |
WANDS JACK R.;DE LA MONTE SUZANNE M.;DEUTCH ALAN H.;GHANBARI HOSSEIN A. |
分类号 |
G01N33/574;A61K39/395;C12N9/64;C12P21/04;G01N33/53 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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