发明名称 |
Stabilized HBc chimer particles as therapeutic vaccine for chronic hepatitis |
摘要 |
<p>Disclosed is a use of a T cell-stimulating amount of a vaccine for manufacturing a medicament to treat chronic hepatitis B. The vaccine comprises an immunogenic amount of chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protein (HBc) that is engineered for both enhanced stability of self-assembled particles and the substantial absence of nucleic acid binding by those particles. The chimeric protein molecule can include one or more immunogenic epitopes peptide-bonded to one or more of the N-terminus, the immunogenic loop or the C-terminus of HBc. The enhanced stability of self-assembled particles is obtained by the presence of at least one heterologous cysteine residue near one or both of the amino-terminus and carboxy-terminus of the chimer molecule.</p> |
申请公布号 |
NZ541702(A) |
申请公布日期 |
2008.08.29 |
申请号 |
NZ20040541702 |
申请日期 |
2004.02.20 |
申请人 |
LORANTIS LIMITED |
发明人 |
PAGE, MARK;FRIEDE, MARTIN;SCHMIDT, ANNETTE ELISABETH;STOBER, DETLEF |
分类号 |
A61K39/00;A61K39/29;C07K14/02;C12N7/04;C12N15/36;(IPC1-7):A61K39/12;A61K39/385;C07K14/00;C07K14/005;C12P21/00;C12N15/09;C12N15/31;C12N15/33;C12N15/51 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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