发明名称 |
IMPROVED PROTEIN EXPRESSION STRAINS |
摘要 |
The use of a means to vary Ubc4p or Ubc5p activity in a fungal cell to control the copy number of a plasmid in the cell. The level of Ubc4p or Ubc5p activity may be reduced/abolished (for example by gene deletion, mutagenesis to provide a less active protein, production of antisense mRNA or production of competitive peptides) to raise the copy number and increase yield of a protein encoded by the plasmid.
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申请公布号 |
CA2295190(C) |
申请公布日期 |
2008.08.26 |
申请号 |
CA19982295190 |
申请日期 |
1998.06.26 |
申请人 |
DELTA BIOTECHNOLOGY LIMITED |
发明人 |
SLEEP, DARRELL |
分类号 |
C12N1/19;C12N15/09;C07K14/765;C07K14/805;C12N1/15;C12N9/00;C12N15/11;C12N15/52;C12N15/81;C12P1/02;C12P21/02;C12R1/865 |
主分类号 |
C12N1/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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