MONOPHOSPHATES AS MUTUAL PRODRUGS OF MUSCARINIC RECEPTOR ANTAGONISTS AND ß-AGONISTS FOR THE TREATMENT OF COPD AND CHRONIC BRONCHITIS

摘要

A mutual prodrug of a MRA and a ß-agonist for formulation for delivery by aerosolization to inhibit pulmonary bronchoconstriction is described. The mutual prodrug is preferably formulated in a small volume solution (10-500 µL) dissolved in a quarter normal saline having pH between 5.0 and 7.0 for the treatment of respiratory tract bronchoconstriction by an aerosol having mass median average diameter predominantly between 1 to 5 µ, produced by nebulization or by dry powder inhaler.