Substituted aminoindane- and aminotetralinecarboxylic acids and the use thereof

摘要

The present application relates to novel substituted aminoindane- and aminotetralinecarboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary diseases.

主权项

1. A compound of the formula (I) in which n represents the number 1 or 2 and A represents a group of the formula in which* denotes the respective point of attachment to the remainder of the molecule,L1 represents straight-chain (C1-C5)-alkanediyl,x represents the number 1, 2 or 3, where one of these CH2 groups may be replaced by —O—,R1A and R1B independently of one another represent hydrogen or methyl,L2 represents a bond or straight-chain (C1-C5)-alkanediyl,Ar represents phenyl or 5- or 6-membered heteroaryl having up to three heteroatoms from the group consisting of N, O and S,R2 represents a substituent selected from the group consisting of fluorine, chlorine, bromine, cyano, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy and trifluoromethoxy,p represents the number 0, 1 or 2,
where in the case where the substituent R2 occurs twice, its respective meanings can be identical or different,L3 represents a bond, —O—, —CH2—, —CH2—CH2— or —CH═CH—andR3 and R4 independently of one another represent hydrogen or a substituent selected from the group consisting of fluorine, chlorine, bromine, cyano, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy and trifluoromethoxy, and salts, solvates and solvates of the salts thereof.