| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing intraorally quickly disintegrable tablets having high disintegrability and sufficient hardness and wear resistance in their normal handling and good in feeling when taken, directly using a conventional pharmaceutical production facility. SOLUTION: The method for producing the intraorally quickly disintegrable tablets comprises the following process wherein a 50% ethanol aqueous solution of polyvinyl pyrrolidone K-30 is added to lactose crystal granule nuclei, and subsequently, the above 50% ethanol aqueous solution of K-30 is sprinkled with a sparingly soluble medicament ethenzamide with its powder physical properties modified by admixing ethenzamide with silicic anhydride beforehand to effect powder coating. The resultant powder-coated granules are then dried and made even into powder-coated granules, which are then admixed with granulated lactose, crystalline cellulose, crospovidon and maltitol. Subsequently, the resultant mixture is admixed with magnesium stearate followed by tableting. COPYRIGHT: (C)2008,JPO&INPIT
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