| 发明名称 |
Flourene Derivative |
| 摘要 |
This invention relates to a novel fluorene derivative having a characteristic structure in which guanidino group or the like functional group is linked to the fluorene structure via carbonyl group, or a salt thereof. The compound of the invention has an advantage in that it has high affinity for serotonin receptor subtypes, particularly for 5-HT<SUB>2B </SUB>receptor and 5-HT<SUB>7 </SUB>receptor, and shows excellent pharmacological effects in comparison with the conventional compounds which have only one of the antagonistic activities of 5-HT<SUB>2B </SUB>receptor and 5-HT<SUB>7 </SUB>receptor, this is useful as a prophylactic antimigraine agent having high safety and excellent effect.
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| 申请公布号 |
US2008200551(A1) |
申请公布日期 |
2008.08.21 |
| 申请号 |
US20050568684 |
申请日期 |
2005.02.17 |
| 申请人 |
YAMADA HIROYOSHI;ITAHANA HIROTSUNE;MORITOMO AYAKO;MATSUZAWA TAKAHO;HARADA KOICHIRO;FUJIYASU JIRO;KOGA YUJI;OKU MAKOTO;OKAZAKI TOSHIO;AKUZAWA SHINOBU;WATANABE TOSHIHIRO |
发明人 |
YAMADA HIROYOSHI;ITAHANA HIROTSUNE;MORITOMO AYAKO;MATSUZAWA TAKAHO;HARADA KOICHIRO;FUJIYASU JIRO;KOGA YUJI;OKU MAKOTO;OKAZAKI TOSHIO;AKUZAWA SHINOBU;WATANABE TOSHIHIRO |
| 分类号 |
A61K31/166;A61K31/343;A61K31/351;A61K31/352;A61K31/357;A61K31/385;A61K31/41;A61K31/4168;A61K31/4196;A61K31/421;A61K31/426;A61K31/438;A61P25/06;C07C233/78;C07C279/22;C07D207/20;C07D209/54;C07D209/96;C07D211/70;C07D221/20;C07D233/50;C07D249/14;C07D257/06;C07D263/28;C07D277/18;C07D303/06;C07D305/14;C07D307/94;C07D309/06;C07D309/20;C07D311/96;C07D317/12;C07D319/14;C07D327/04;C07D335/04;C07D339/06 |
主分类号 |
A61K31/166 |
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