Divalent metal-ion loaded nano-transport system having a dendritic architecture useful for therapy
摘要
<p>Described is the use of a nanocarrier having a dendritic structure which is composed of a dendritic core and at least one shell for the non-covalent encapsulation and/or transport of divalent metal-ions, preferably Cu-ions or Zn(II)-ions. Also described is a pharmaceutical composition containing such nanocarrier complexed divalent metal-ions in a non-covalent encapsulated form. Finally several therapeutic uses of such a nanocarrier divalent metal-ion complex are described, for example for slowing down ageing or for the treatment of Cu-ion transport disorders like Alzheimer's disease (AD) or Menkes disease.</p>
申请公布号
EP1958624(A1)
申请公布日期
2008.08.20
申请号
EP20070003315
申请日期
2007.02.16
申请人
FREIE UNIVERSITAET BERLIN
发明人
MULTHAUP, GERD, PROF., DR.;HAAG, RAINER, PROF., DR.;TREIBER, CARINA, DR.