MATERIALS AND METHODS FOR ABCB1 POLYMORPHIC VARIANT SCREENING, DIAGNOSIS, AND TREATMENT

摘要

The invention provides methods and materials for screening for polymorphic variants in ABCB1 and diagnosing altered susceptibilities for drug-induced heart rhythm irregularities based on the same. These methods allow better treatment regimens for using drugs that bind a protein encoded by the ABCB1 and/or induce heart rhythm irregularities such as the anti-cancer drug FK228.