| 摘要 |
<p>Preparation of 5-hydroxymethyl-furfural (I) from a saccharide (III) with 6C in the monosaccharide unit, via 2-acyloxymethyl-furfural (II), involves (a) reacting (III) with an acid or an acidic ion exchanger; (b) adding a carboxylic acid anhydride and/or chloride and reacting to give (II); (c) dissolving (II) in an alcohol; and (d) reacting with a base. Preparation of 5-hydroxymethyl-furfural (I) from a saccharide (III) with 6C in the monosaccharide unit, via 2-acyloxymethyl-furfurals of formula (II), involves: (a) reacting (III) with (i) an acid (other than an acidic ion exchanger (AIE)) in presence of alkali(ne earth) metal and/or aluminum cations or (ii) an AIE in H-form in presence of a polar aprotic solvent (the AIE subsequently being removed); (b) adding an anhydride and/or chloride of a carboxylic acid of formula R(COOH) x (IV) and reacting to give (II); (c) dissolving (II) in an alcohol; and (d) reacting with a base selected from (i) alkali metal (bi)carbonates, alkaline earth metal carbonates, hydroxides or basic salts and/or aluminum carbonate, hydroxide oxide-hydroxide or basic salts and (ii) basic ion exchangers in OH-form. x : 1 or 2; R : alkyl, alkenyl, aryl or heteroaryl if x = 1; or alkylene, alkenylene, arylene or heteroarylene if x = 2. An independent claim is included for the preparation of (II) by steps (a) and (b) of the process for preparing (I). [Image] ACTIVITY : Antibacterial; Cytostatic. MECHANISM OF ACTION : None given.</p> |
