发明名称 |
ALLOSTERIC MODULATORS OF THE A1 ADENOSINE RECEPTOR |
摘要 |
The present invention provides compounds of formula (I) wherein R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB> and Q have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric modulators of the A<SUB>1</SUB> adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A<SUB>1</SUB> adenosine receptor. Accordingly, the compounds of formula (I) may be employed for treatment of pain, in particular, chronic pain such as neuropathic pain; cardiac disease or disorder such as cardiac disarrhythmias, e.g., peroxysmal supraventricular tachycardia, angina, myocardial infarction and stroke; neurological disease or injury; sleep disorder; epilepsy; and depression. |
申请公布号 |
WO2008063984(A3) |
申请公布日期 |
2008.08.14 |
申请号 |
WO2007US84490 |
申请日期 |
2007.11.13 |
申请人 |
KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC.;BARALDI, PIER, GIOVANNI;MOORMAN, ALLAN, R.;ROMAGNOLI, ROMEO |
发明人 |
BARALDI, PIER, GIOVANNI;MOORMAN, ALLAN, R.;ROMAGNOLI, ROMEO |
分类号 |
A61K31/497 |
主分类号 |
A61K31/497 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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