摘要 |
The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula where R-Li, Na, K, <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>--H, -NH<SUB>2</SUB>, -Br, -Cl, -OH, -COOH,<?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>B--N-, -CH-, Z=-CH-, -N-,<?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>A=-N- at B--N-, Z=-CH-,<?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>A=-CH- at B--N-, Z=-CH-,<?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>A=-CH- at B--N-, Z=-N-,<?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>A=-CH- at B--CH-, Z=-CH-,<?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>A=-CH- at B--CH-, Z=-N-,<?in-line-formulae description="In-line Formulae" end="tail"?> and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base.
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