发明名称 |
Immunosuppression compound and treatment method |
摘要 |
<p>A method and compound for suppressing an immune response in a mammalian subject, for the treatment or prevention of an autoimmune condition or transplantation rejection are disclosed. The compound is an antisense oligonucleotide analog compound having a targeting sequence complementary to a preprocessed CTLA-4 mRNA region identified by SEQ ID NO: 1, spanning the splice junction between intron 1 and exon 2 of the preprocessed mRNA of the subject. The compound is effective, when administered to a subject, to form within host cells, a heteroduplex structure (i) composed of the preprocessed CTLA-4 mRNA and the oligonucleotide compound, (ii) characterized by a Tm of dissociation of at least 45° C., and (iii) resulting in an increased ratio of processed mRNA encoding ligand-independent CTLA-4 to processed mRNA encoding full-length CTLA-4.</p> |
申请公布号 |
EP1954836(A2) |
申请公布日期 |
2008.08.13 |
申请号 |
EP20060844293 |
申请日期 |
2006.11.08 |
申请人 |
AVI BIOPHARMA, INC. |
发明人 |
MOURICH, DAN, V.;IVERSEN, PATRICK, L.;WELLER, DWIGHT, D. |
分类号 |
C12N15/113;A61K31/7088;C07H21/04 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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