| 摘要 |
An oral sustained-release triple layer tablet is provided to control release of a physiologically active material effectively from a fast-release intermediate layer by an upper and a lower layers forming a gelated layer on the side of the intermediate layer through swelling of the upper and lower layers when it is exposed to a water-soluble medium. An oral sustained-release triple layer tablet comprising a fast release intermediate layer including a physiologically active material and an upper and a lower layers including a swelling polymer is characterized in that the side of the fast release intermediate layer is exposed and the upper and the lower layers are swollen by the contact of an aqueous medium to surround the exposed side of the fast release intermediate layer, thereby controlling the release of the active material, wherein the physiologically active material is selected from the group consisting of doxazosin, terazosin, tamsulosin, simvastatin, lovastatin, fluvastatin, acetaminophen, zaltoprofen and tramadol and the swelling polymer is selected from the group consisting of polyethylene oxide, hydroxypropylmethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, polyvinylalcohol and carbomer.
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