PEPTIDE CAPABLE OF ACTIVATING WNT SIGNALING

摘要

Disclosed is a peptide or a salt thereof which has a relatively low molecular weight and is useful for the regulation of proliferation or differentiation of a stem cell such as a neural stem cell and a hematopoietic stem cell or the treatment of cancer, a neurological disease or other diseases such as diabetes. Specifically disclosed is a peptide of the following item (1) or (2) or a salt thereof: (1) a peptide comprising the amino acid sequence depicted in SEQ ID NO:1; or (2) a peptide which comprises an amino acid sequence having the substitution, deletion or addition of one or several amino acid residues in the amino acid sequence depicted in SEQ ID NO:1, and which has at least one Wnt signaling activation activity selected from the group consisting of an activity of inducing the adhesion of a PC12 cell, an activity of promoting the differentiation of a neural stem cell and an activity of accelerating the intracellular accumulation of ß-catenin.