Provided are pharmaceutical formulations comprising sustained release par ticles each having an inner core bead comprising an active pharmaceutical in gredient an intermediate coating substantially surrounding the inner core be ad, and an outer coating substantially surrounding the intermediate coating comprising a pH independent polymer. Also provided is a pharmaceutical formu lation comprising two bead populations wherein each of the first and second bead populations have a different drug release profile. Also provided is a m ethod of preparing an extended release dosage composition comprising one or more bead populations.
