A peripheral device control system and a peripheral device control method are provided. The peripheral device control system includes: a peripheral device controller generating a connection-alarming interrupt when a peripheral device is connected thereto; a first processor including a processor core connected directly to the peripheral device controller; and a path setting unit setting a connection path for connecting the peripheral device controller to one of the processor core and a second processor with reference to a predetermined value when the connection-alarming interrupt is input from the peripheral device controller. Here, the second processor communicates with the first processor and the peripheral device controller is controlled directly by one of the processor core and the second processor in which the connection path is set. Regardless of the operation of the application processor, it is possible to allow the host processor to directly control a USB device connected to a USB controller.
