Method for preventing HIV-1 infection of CD4 cells

摘要

This invention provides methods for inhibiting fusion of HIV-1 to CD4^- cells which comprise contacting CD4^- cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4⁺ cells is inhibited. This invention also provides methods for inhibiting HIV-1 infection of CD4^- cells which comprise contacting CD4⁺ cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4⁺ cells is inhibited, thereby inhibiting the HIV-1 infection. This invention provides non-chemokine agents capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4⁺ cells. This invention also provides pharmaceutical compositions comprising an amount of the non-chemokine agent capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4⁺ cells effective to prevent fusion of HIV-1 to CD4⁺ cells and a pharmaceutically acceptable carrier.