MODELS FOR VACCINE ASSESSMENT

摘要

The present invention is directed to methods for constructing and using i n vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologies and other chemicals. The present invention comprises both in vivo and in vit ro models of aspects of human immunity that are useful for assessing the int eraction of substances with the immune system, and thus can be used to accel erate and improve the accuracy and predictability of, for example, vaccine, drug, biologic, immunotherapy, cosmetic and chemical development. The invent ion is also useful for the generation of human monoclonal and polyclonal ant ibodies.