| 摘要 |
<p>Disclosed is a compound useful as a type I 11²hydroxysteroid dehydrogenase inhibitor.
A compound represented by the formula:
a pharmaceutically acceptable salt or solvate thereof,
wherein
R 1 is optionally substituted alkyl or the like,
one of R 2 and R 4 is a group of formula: -Y-R 5 ,
wherein Y is -O- or the like,
R 5 is substituted alkyl (the substituent is optionally substituted cycloalkyl or the like), optionally substituted branched alkyl or the like,
the other of R 2 and R 4 is hydrogen or optionally substituted alkyl,
R 3 is a group of formula: -C(=O)-Z-R 6 ,
wherein Z is -NR 7 - or -NR 7 -W-,
R 6 is optionally substituted cycloalkyl or the like,
R 7 is hydrogen or optionally substituted alkyl,
W is optionally substituted alkylene,
X is =N- or the like,
with the proviso that compounds wherein R 2 is 2-(morphorino)ethoxy, R 3 is N-(1-adamantyl)carbamoyl and R 1 is benzyl are excluded.</p> |
