SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1)

摘要

This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R₁, R₂, R₃, and R₄ are each H, alkyl, , alkanoyl, halo, OH, aryl optionally substituted with R₈, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, pertluoroalkoxy; R₅ is H, alkyl, perfluoroalkyl, aryl optionally substituted with R₅, alkanoyl, aroyl optionally substituted with R₈; R₆ is H, alkyl, alkylaryl, benzyl optionally substituted with R₈, alkanoyl, aroyl optionally substituted with R₈; R₇ is H, alkyl, alkylaryl, aryl optionally substituted with R₈; n is 0 - 6 ; A is COOH, or an acid mimic such as tetraazole, SO₃H, PO₃H₂, tetronic acid, etc.; R₈ is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.