| 发明名称 |
TGF-beta SIGNAL TRANSMISSION MECHANISM INHIBITOR, SMAD DEGRADATION INDUCTOR, SMAD UBIQUITIN FORMATION PROMOTER, SMURF DEGRADATION INDUCTOR, SMURF UBIQUITIN FORMATION PROMOTER, METHOD FOR INHIBITING TGF-beta SIGNAL TRANSMISSION MECHANISM, METHOD FOR INDUCING SMAD DEGRADATION, METHOD FOR PROMOTING SMAD UBIQUITIN FORMATION, METHOD FOR INDUCING SMURF DEGRADATION, AND METHOD FOR PROMOTING SMURF UBIQUITIN FORMATION |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a TGF-βsignal transmission mechanism inhibitor. <P>SOLUTION: An estrogen receptor ligand, a glucocorticoid receptor ligand, a vitamin D receptor ligand, a progesterone receptor ligand, or a retinoic acid receptor ligand is used as a TGF-βsignal transmission mechanism inhibitor. The TGF-βsignal transmission mechanism inhibitor is useful for treating and researching cancers (breast cancer, lung cancer, uterine cancer, prostatic cancer, pancreatic cancer, melanoma), pulmonary fibrosis, renal fibrosis, and hepatocirrhosis. <P>COPYRIGHT: (C)2008,JPO&INPIT</p> |
| 申请公布号 |
JP2008174463(A) |
申请公布日期 |
2008.07.31 |
| 申请号 |
JP20070007436 |
申请日期 |
2007.01.16 |
| 申请人 |
ANKHS:KK |
发明人 |
YANAGISAWA JUN;ICHIHARA NARIYASU |
| 分类号 |
A61K45/00;A61K31/565;A61K38/00;A61K48/00;A61P1/16;A61P11/00;A61P13/12;A61P35/00;A61P35/04;A61P43/00;C12N5/10;C12N15/09;C12Q1/68;G01N33/15;G01N33/50 |
主分类号 |
A61K45/00 |
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