DOMAIN-EXCHANGED RECOMBINANT ANTIBODY COMPOSITION

摘要

Disclosed are: a recombinant antibody composition which has the substitution of polypeptides respectively comprising CH1 domain and CH2 domain of the constant region in human IgG1 antibody by polypeptides respectively comprising amino acid sequences corresponding to the amino acid sequences located in the same positions in human IgG3 antibody as numbered according to the EU index as in Kabat et al. (hereinbelow, simply referred to as "EU index"), and which has a higher CDC activity than those of human IgG1 antibody and human IgG3 antibody and a protein A-binding activity equivalent to that of human IgG1 antibody; an antibody molecule contained in the recombinant antibody composition or DNA encoding the heavy-chain constant region of the antibody molecule; a transformant produced by introducing the DNA into a host cell; a method for producing a recombinant antibody composition by using the transformant; and a pharmaceutical agent comprising the antibody composition as an active ingredient.