发明名称 Process For the Preparation of Polynuclear Ferric Hydroxide-Saccaride Complexes
摘要 The invention discloses a process for preparing a polynuclear ferric hydroxide-saccharide complex, including: adding an aqueous solution of an alkaline substance drop-wise into an aqueous solution of iron salt at a temperature of 5-20° C. until pH 6-8, collecting the polynuclear ferric hydroxide from the reaction mixture by a conventional method; reacting the polynuclear ferric hydroxide with a saccharide in a solution of an alkaline substance for 10-40 hours at 106-125° C. under pH 10-12, resulting in a crude product having an isoelectric point of 4.4-5.3 and a weight average molecular weight of 20,000-100,000 Daltons, and then harvesting the polynuclear ferric hydroxide-saccharide complex from the crude product. The process can precisely control the molecular weight of the polynuclear ferric hydroxide-saccharide complex without an effect on the other characteristics of the product, for example its saccharide content or isoelectric point etc. Furthermore, it is very simple and readily applicable in industry.
申请公布号 US2008176941(A1) 申请公布日期 2008.07.24
申请号 US20060911449 申请日期 2006.04.12
申请人 CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. 发明人 XIAO JINMAI;DENG JIE;FENG JINHUA;XIAO BO
分类号 A61K31/295 主分类号 A61K31/295
代理机构 代理人
主权项
地址