TOPICAL THERAPIES FOR ORAL MUCOSITIS AND OTHER CONDITIONS

摘要

A method for treating oral mucositis in a subject comprises topically administering to an oral mucosal surface of the subject phenytoin or a pharmaceutically acceptable salt thereof in an amount effective to inhibit mucosal degeneration or promote mucosal regeneration, and optionally an analgesic agent in an amount effective, in combination with the phenytoin or salt thereof, to reduce pain associated with the oral mucositis. The phenytoin or salt thereof and optionally the analgesic agent can be administered in a pharmaceutical composition comprising an excipient vehicle suitable for intraoral administration, said composition being bioadhesive to an oral mucosal surface, for example having at least one non-lipoidal internal phase and at least one lipoidal external phase that is bioadhesive to said surface.