| 摘要 |
<p>Animal testing, wherein the animals have disease state characteristics substantially equivalent to those found in humans, may be utilized to evaluate the efficacy of medical devices and/or therapeutic agents. In one embodiment, a method of inducing one or more vascular diseases in a mammal having at least one of an apoE gene and LDL-receptor gene deleted is described. The method comprises: accelerating athereosclorosis in the mammalian vasculature through the introduction of a high fat, high cholesterol diet; and introducing, via systemic delivery, angiotensin II at a predetermined time to induce and accelerate vascular inflammation.</p> |
