| 摘要 |
<p>The invention relates to compounds of Formula I:
or a pharmaceutically effective salt, solvate, hydrate, or prodrug thereof, wherein: R 1 is hydrogen, hydroxy, or halogen; R 2 is hydrogen or ±-hydroxy; R 3 is hydroxy, NH(CH 2 ) m SO 3 H, or NH(CH 2 ) n CO 2 H; R 4 is hydrogen, alkyl, or halogen; R 5 is unsubstituted or substituted alkyl, or aryl; R 6 is hydrogen or R 5 and R 6 taken together with the carbons to which they are attached form a ring of size 3, 4, 5, or 6 atoms; m is an integer 0, 1, 2, 3, 4, or 5, and n is an integer 0, 1, 2, 3, 4, or 5. The compounds of Formula I are TGR5 modulators useful for the treatment of various diseases.</p> |
