发明名称 |
SOLUBLE COMPOSITIONS OF TRIPHENYLETHYLENE ANTIESTROGENS |
摘要 |
The invention relates to aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxylic acid having 1-5 carbon atoms, wherein the carbon chain may further contain 1-4 hydroxyl, 1-3 oxo, or one or several halogen substituents, or a corresponding anion thereof, or methanesulfonic acid or its corresponding anion, in molar excess with respect to the triphenylethylene antiestrogen, optionally together with an organic water miscible co-solvent such as polyethylene glycol (PEG), propylene glycol, ethanol or isopropanol.
|
申请公布号 |
CA2355175(C) |
申请公布日期 |
2008.07.15 |
申请号 |
CA19992355175 |
申请日期 |
1999.12.16 |
申请人 |
ORION CORPORATION |
发明人 |
AF URSIN, KAIJA;KIESVAARA, JUHA;KANANEN, MIKKO;KORTESUO, PIRJO;SALMIA, JUKKA;NISKANEN, HEIKKI;ORN, GUNILLA |
分类号 |
A61K31/138;A61K9/08;A61K31/40;A61K31/4025;A61K31/4535;A61K47/10;A61K47/12;A61K47/20;A61P35/00 |
主分类号 |
A61K31/138 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|