PHARMACEUTICAL FOR PROTECTION OF MOTOR NERVE IN PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS

摘要

Disclosed is a pharmaceutical for use in the protection of a motor nerve in a patient suffering from amyotrophic lateral sclerosis, which comprises a combination of (a) (2R)-2-propyloctanoic acid or a salt thereof and (b) a therapeutic agent for amyotrophic lateral sclerosis such as riluzole. A pharmaceutical comprising a combination of (a) (2R)-2-propyloctanoic acid in an oral dose amount of about 1200 mg per dose at a dose frequency of once a day and (b) riluzole in an oral dose amount of about 50 mg per dose at a dose frequency of twice a day is useful for the protection of a motor nerve in a patient suffering from amyotrophic lateral sclerosis. The pharmaceutical can also prevent the decrease in an inhalation/respiratory function associated with the progression of the disease condition and improve the survival rate in the patient.