发明名称 |
COMPOSITIONS COMPRISING CROSS-SPECIES-SPECIFIC ANTIBODIES AND USES THEREOF |
摘要 |
The present invention relates to uses of bispecific antibodies exhibiting cross-species specificity for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of the same in non-human species and humans. The present invention moreover relates to methods for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of said bispecific anti-bodies exhibiting cross-species specificity. The present invention also relates to methods of measuring the biological activity and/or efficacy of such bispecific antibodies exhibiting cross-species specificity. In addition, the present invention relates to pharmaceutical compositions comprising bispecific single chain antibodies exhibiting cross-species specificity and to methods for the preparation of pharmaceutical compositions comprising said bispecific single chain antibodies exhibiting cross-species specificity for the treatment of diseases. |
申请公布号 |
EP1940881(A2) |
申请公布日期 |
2008.07.09 |
申请号 |
EP20060806155 |
申请日期 |
2006.10.10 |
申请人 |
MICROMET AG |
发明人 |
KISCHEL, ROMAN;RAUM, TOBIAS;SCHLERETH, BERND;RAU, DORIS;CIERPKA, RONNY;KUFER, PETER |
分类号 |
C07K16/28;A61K39/395;A61P35/00;C07K16/30;C12N15/13 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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